The Complex Conformational Dynamics of Neuronal Calcium Sensor-1: A Single Molecule Perspective.

ABSTRACT: The human neuronal calcium sensor-1 (NCS-1) is a multispecific two-domain EF-hand protein expressed predominantly in neurons and is a member of the NCS protein family. Structure-function relationships of NCS-1 have been extensively studied showing that conformational dynamics linked to diverse ion-binding is important to its function. NCS-1 transduces Ca²⁺ changes in neurons and is linked to a wide range of neuronal functions such as regulation of neurotransmitter release, voltage-gated Ca²⁺ channels and neuronal outgrowth. Defective NCS-1 can be deleterious to cells and has been linked to serious neuronal disorders like autism. Here, we review recent studies describing at the single molecule level the structural and mechanistic details of the folding and misfolding p

SUBMITTER: Choudhary D 

PROVIDER: S-EPMC6304440 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature