Integrated Analysis of MicroRNA (miRNA) and mRNA Profiles Reveals Reduced Correlation between MicroRNA and Target Gene in Cancer.

ABSTRACT:

Background

Accumulating evidences demonstrated that microRNA-target gene pairs were closely related to tumorigenesis and development. However, the correlation between miRNA and target gene was insufficiently understood, especially its changes between tumor and normal tissues.

Objectives

The aim of this study was to evaluate the changes of correlation of miRNAs-target pairs between normal and tumor.

Materials and methods

5680 mRNA and 5740 miRNA expression profiles of 11 major human cancers were downloaded from the Cancer Genome Atlas (TCGA). The 11 cancer types were bladder urothelial carcinoma, breast invasive carcinoma, head and neck squamous cell carcinoma, kidney chromophobe, kidney renal clear cell carcinoma, kidney renal papillary cell carcinoma, liver hepatocel

SUBMITTER: Li X 

PROVIDER: S-EPMC6304515 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature