Exploring the Mechanism of Danshen against Myelofibrosis by Network Pharmacology and Molecular Docking.

ABSTRACT: Danshen (Salvia miltiorrhiza Bunge), a natural powerful drug for various conditions treatment, has traditionally been used in Asian countries for centuries as anticancer agent, anti-inflammatory agent, and antioxidant. More recently, it is explored in combination with other herbs for skeletal diseases therapy; bone-targeting compounds with pharmacological activities have been isolated from various sources of traditional Chinese medicine (TCM), including Danshen. In this case, some evidence supports that Danshen may treat myelofibrosis (MF) by exerting its antitumor effect. To study the specific mechanism of Danshen in the treatment of MF, we used bioinformatics databases to determine its active ingredients. Then, identification of target proteins related to MF was made using a network phar

SUBMITTER: Li J 

PROVIDER: S-EPMC6304517 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature