Altered Functional Network Affects Amyloid and Structural Covariance in Alzheimer's Disease.

ABSTRACT:

Background

We aimed to investigate how altered intrinsic connectivity networks (ICNs) affect pathologic changes of Alzheimer's disease (AD) at a network-based level.

Methods

Thirty normal controls (NCs), 23 patients with AD-mild cognitive impairment (MCI), and 20 patients with AD-dementia were enrolled. We compared the organization of grey matter structural covariance and functional connectivity in ICNs between NCs and all AD patients who were amyloid β (Aβ)-positive. We further used seed-based interregional covariance analysis to compare structural and Aβ plaque covariance in default mode network (DMN) between AD-MCI and AD-dementia groups.

Results

The patients with AD had increased functional interregional covariance among the regions of the ICN

SUBMITTER: Chang YT 

PROVIDER: S-EPMC6304529 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature