Toxicity Evaluation of a Novel Magnetic Resonance Imaging Marker, CoCl2-N-Acetylcysteine, in Rats.

ABSTRACT: C4 (cobalt dichloride-N-acetylcysteine [1% CoCl₂:2% NAC]) is a novel magnetic resonance imaging contrast marker that facilitates visualization of implanted radioactive seeds in cancer brachytherapy. We evaluated the toxicity of C4. Rats were assigned to control (0% CoCl₂:NAC), low-dose (0.1% CoCl₂:2% NAC), reference-dose (C4), and high-dose (10% CoCl₂:2% NAC) groups. Agent was injected into the left quadriceps femoris muscle of the rats. Endpoints were organ and body weights, hematology, and serum chemistry and histopathologic changes of tissues at 48 hours and 28 and 63 days after dosing. Student's t tests were used. No abnormalities in clinical signs, terminal body and organ weights, or hematologic and serum chemistry were noted, and no

SUBMITTER: Wang L 

PROVIDER: S-EPMC6304599 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature