Left ventricular dysfunction after two hours of polarizing or depolarizing cardioplegic arrest in a porcine model.

ABSTRACT:

Introduction

This experimental study compares myocardial function after prolonged arrest by St. Thomas' Hospital polarizing cardioplegic solution (esmolol, adenosine, Mg²⁺) with depolarizing (hyperkalaemic) St. Thomas' Hospital No 2, both administered as cold oxygenated blood cardioplegia.

Methods

Twenty anaesthetized pigs on tepid (34°C) cardiopulmonary bypass (CPB) were randomised to cardioplegic arrest for 120 min with antegrade, repeated, cold, oxygenated, polarizing (STH-POL) or depolarizing (STH-2) blood cardioplegia every 20 min. Cardiac function was evaluated at Baseline and 60, 150 and 240 min after weaning from CPB, using a pressure-conductance catheter and epicardial echocardiography. Regional tissue blood flow, cleaved caspase-3 activity and levels of

SUBMITTER: Aass T 

PROVIDER: S-EPMC6304685 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature