Deleterious alleles in the context of domestication, inbreeding, and selection.

ABSTRACT: Each individual has a certain number of harmful mutations in its genome. These mutations can lower the fitness of the individual carrying them, dependent on their dominance and selection coefficient. Effective population size, selection, and admixture are known to affect the occurrence of such mutations in a population. The relative roles of demography and selection are a key in understanding the process of adaptation. These are factors that are potentially influenced and confounded in domestic animals. Here, we hypothesize that the series of events of bottlenecks, introgression, and strong artificial selection associated with domestication increased mutational load in domestic species. Yet, mutational load is hard to quantify, so there are very few studies available revealing the relevanc

SUBMITTER: Bosse M 

PROVIDER: S-EPMC6304688 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature