Monomer-Induced Customization of UV-Cured Atelocollagen Hydrogel Networks.

ABSTRACT: The covalent functionalization of type I atelocollagen with either 4-vinylbenzyl or methacrylamide residues is presented as a simple synthetic strategy to achieve customizable, cell-friendly UV-cured hydrogel networks with widespread clinical applicability. Molecular parameters, i.e., the type of monomer, degree of atelocollagen functionalization and UV-curing solution, have been systematically varied and their effect on gelation kinetics, swelling behavior, elastic properties, and enzymatic degradability investigated. UV-cured hydrogel networks deriving from atelocollagen precursors functionalized with equivalent molar content of 4-vinylbenzyl (F _4VBC = 18 ± 1 mol.%) and methacrylamide (F _MA = 19 ± 2 mol.%) adducts proved to display remark

SUBMITTER: Liang H 

PROVIDER: S-EPMC6304747 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature