Dynamic Communications Between GABA_A Switch, Local Connectivity, and Synapses During Cortical Development: A Computational Study.

ABSTRACT: Several factors regulate cortical development, such as changes in local connectivity and the influences of dynamical synapses. In this study, we simulated various factors affecting the regulation of neural network activity during cortical development. Previous studies have shown that during early cortical development, the reversal potential of GABA_A shifts from depolarizing to hyperpolarizing. Here we provide the first integrative computational model to simulate the combined effects of these factors in a unified framework (building on our prior work: Khalil et al., 2017a,b). In the current study, we extend our model to monitor firing activity in response to the excitatory action of GABA_A. Precisely, we created a Spiking Neural Network model that included certain bioph

SUBMITTER: Khalil R 

PROVIDER: S-EPMC6304749 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature