Grading of Neuroendocrine Carcinomas: Correlation of ⁶⁸Ga-PET/CT Scan with Tissue Biomarkers.

ABSTRACT: There is a growing need for more accurate biomarkers to facilitate the diagnosis and prognosis of patients with grade (G) 3 neuroendocrine carcinomas (NECs). In particular, the discrimination between well-differentiated neuroendocrine carcinomas (WD-NECs) and poorly differentiated neuroendocrine carcinomas (PD-NECs) is still an unmet need. We previously showed that ⁶⁸Gallium-(⁶⁸Ga-) PET/CT positivity is a prognostic factor in patients with gastroenteropancreatic (GEP) G3 NECs, correlating with a better outcome in terms of overall survival. Here, we hypothesize that ⁶⁸Ga-PET/CT could help to discriminate between WD-NECs and PD-NECs, adding complementary information to that obtained from morphologic and biologic factors. A retrospective, single-institution st

SUBMITTER: Liverani C 

PROVIDER: S-EPMC6304840 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature