Obesity May Provide Pro-ILC3 Development Inflammatory Environment in Asthmatic Children.

ABSTRACT: The prevalence of obesity in children has dramatically increased in the last few decades, and obesity has also emerged as an important risk factor for asthma. Innate mechanisms have been shown to be involved in both diseases, particularly through the recently described innate lymphoid cells (ILCs), in which ILC3s have been linked to obesity both in human and in murine models. The aim of this study was to explore whether being overweight in asthmatic children was associated with elevated circulating ILC3 or elevated messenger RNA (mRNA) levels of RORC, IL-17A, and IL-22. Our results showed significantly elevated ILC3 frequencies in overweight asthmatic children compared with nonoverweight controls based on the detection of Lin⁺CD127⁺IL-23R⁺ cells by flow cyt

SUBMITTER: Wu Y 

PROVIDER: S-EPMC6304845 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature