Estimating the proportion of bystander selection for antibiotic resistance among potentially pathogenic bacterial flora.

ABSTRACT: Bystander selection-the selective pressure for resistance exerted by antibiotics on microbes that are not the target pathogen of treatment-is critical to understanding the total impact of broad-spectrum antibiotic use on pathogenic bacterial species that are often carried asymptomatically. However, to our knowledge, this effect has never been quantified. We quantify bystander selection for resistance for a range of clinically relevant antibiotic-species pairs as the proportion of all antibiotic exposures received by a species for conditions in which that species was not the causative pathogen ("proportion of bystander exposures"). Data sources include the 2010-2011 National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey, the Human Microbiome Project, an

SUBMITTER: Tedijanto C 

PROVIDER: S-EPMC6304942 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature