GABA release selectively regulates synapse development at distinct inputs on direction-selective retinal ganglion cells.

ABSTRACT: Synaptic inhibition controls a neuron's output via functionally distinct inputs at two subcellular compartments, the cell body and the dendrites. It is unclear whether the assembly of these distinct inhibitory inputs can be regulated independently by neurotransmission. In the mammalian retina, γ-aminobutyric acid (GABA) release from starburst amacrine cells (SACs) onto the dendrites of on-off direction-selective ganglion cells (ooDSGCs) is essential for directionally selective responses. We found that ooDSGCs also receive GABAergic input on their somata from other amacrine cells (ACs), including ACs containing the vasoactive intestinal peptide (VIP). When net GABAergic transmission is reduced, somatic, but not dendritic, GABA_A receptor clusters on the ooDSGC increased in number

SUBMITTER: Bleckert A 

PROVIDER: S-EPMC6304984 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature