Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch.

ABSTRACT: Atopic dermatitis (AD) is the most common skin disease in children. It is characterized by relapsing inflammation, skin-barrier defects, and intractable itch. However, the pathophysiology of itch in AD remains enigmatic. Here, we examine the contribution of Tmem79, an orphan transmembrane protein linked to AD in both mice and humans. We show that Tmem79 is expressed by both keratinocytes and sensory neurons, but that loss of keratinocytic Tmem79 is sufficient to elicit robust scratching. Tmem79^-/- mice demonstrate an accumulation of dermal mast cells, which are diminished following chronic treatment with cyclooxygenase inhibitors and an EP3 receptor antagonist. In Tmem79^-/- mice, mast cell degranulation produces histami

SUBMITTER: Emrick JJ 

PROVIDER: S-EPMC6305010 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature