Development of New Tools to Detect Colistin-Resistance among Enterobacteriaceae Strains.

ABSTRACT: The recent discovery of the plasmid-mediated mcr-1 gene conferring resistance to colistin is of clinical concern. The worldwide screening of this resistance mechanism among samples of different origins has highlighted the urgent need to improve the detection of colistin-resistant isolates in clinical microbiology laboratories. Currently, phenotypic methods used to detect colistin resistance are not necessarily suitable as the main characteristic of the mcr genes is the low level of resistance that they confer, close to the clinical breakpoint recommended jointly by the CLSI and EUCAST expert systems (S ≤ 2 mg/L and R > 2 mg/L). In this context, susceptibility testing recommendations for polymyxins have evolved and are becoming difficu

SUBMITTER: Bardet L 

PROVIDER: S-EPMC6305056 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature