Evaluation of collagenase-3 matrix metalloproteinase-13 gene-associated polymorphisms 11A/12A and -77A/G and its associated alleles with and without periodontitis.

ABSTRACT:

Context

Connective tissue devastation in periodontitis and other chronic inflammatory diseases is a major concern. There are several inflammatory mediators associated with this process among which matrix metalloproteinases (MMPs) play a predominant role. Collagen degradation is primarily mediated by the collagenases. MMP-13 is familiar as collagenase-3, which has the aptitude to humiliate fibrillar collagen.

Aims

This study aims to evaluate MMP-13 promoter polymorphism, 11A/12A, and -77A/G and associated alleles in patients with and without chronic periodontitis (CP).

Settings and design

This was an observational case-control study.

Materials and methods

Of the total 100 patients, 50 with CP (test group) and 50 without CP (Control group), blood was collected fo

SUBMITTER: Prasanna JS 

PROVIDER: S-EPMC6305098 | biostudies-literature | 2018 Nov-Dec

REPOSITORIES: biostudies-literature