Thioredoxin interacting protein promotes invasion in hepatocellular carcinoma.

ABSTRACT:

Background

Considerable evidence suggests that oxidative stress plays an essential role in the progression of hepatocellular carcinoma (HCC). While acquired resistance to oxidative stress is the main driver of aggressive cell phenotype, the underlying mechanisms remain unknown. Here, we tested the hypothesis that elevated expression of Thioredoxin-interacting protein (TXNIP) is a main regulator of the aggressive phenotype in HCC.

Materials and methods

To test this hypothesis, we measured TXNIP expression levels in 11 HCC cell lines by qPCR and western blotting. In addition, 80 pairs of HCC tissues and matched liver tissues of 73 cases, as well as 11 normal liver tissue samples were examined by immunohistochemistry. Besides, TXNIP expression levels were analyzed by Oncomine P

SUBMITTER: Gunes A 

PROVIDER: S-EPMC6305144 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature