Social and anxiety-like behaviors contribute to nicotine self-administration in adolescent outbred rats.

ABSTRACT: Both emotional and social traits interact with genetic factors to influence smoking behavior. We previously established a socially acquired nicotine intravenous self-administration model where social learning of a nicotine-associated odor cue reversed conditioned flavor aversion and promoted nicotine intake. In this study, we first phenotyped ~800 adolescent heterogeneous stock rats in open field, novel object interaction, social interaction, elevated plus maze, and marble burying behaviors. These rats were then phenotyped on socially acquired nicotine self-administration. We found 243 significant correlations between different behavioral tests. Principal component regression analysis found that ~10-20% of the variance in nicotine-related measures, such as intake during the first or the la

SUBMITTER: Wang T 

PROVIDER: S-EPMC6305389 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature