PhageWeb - Web Interface for Rapid Identification and Characterization of Prophages in Bacterial Genomes.

ABSTRACT: This study developed a computational tool with a graphical interface and a web-service that allows the identification of phage regions through homology search and gene clustering. It uses G+C content variation evaluation and tRNA prediction sites as evidence to reinforce the presence of prophages in indeterminate regions. Also, it performs the functional characterization of the prophages regions through data integration of biological databases. The performance of PhageWeb was compared to other available tools (PHASTER, Prophinder, and PhiSpy) using Sensitivity (Sn) and Positive Predictive Value (PPV) tests. As a reference for the tests, more than 80 manually annotated genomes were used. In the PhageWeb analysis, the Sn index was 86.1% and the PPV was approximately 87%, while the second bes

SUBMITTER: de Sousa AL 

PROVIDER: S-EPMC6305541 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature