UTRme: A Scoring-Based Tool to Annotate Untranslated Regions in Trypanosomatid Genomes.

ABSTRACT: Most signals involved in post-transcriptional regulatory networks are located in the untranslated regions (UTRs) of the mRNAs. Therefore, to deepen our understanding of gene expression regulation, delimitation of these regions with high accuracy is needed. The trypanosomatid lineage includes a variety of parasitic protozoans causing a significant worldwide burden on human health. Given their peculiar mechanisms of gene expression, these organisms depend on post-transcriptional regulation as the main level of gene expression control. In this context, the definition of the UTR regions becomes of key importance. We have developed UTR-mini-exon (UTRme), a graphical user interface (GUI) stand-alone application to identify and annotate 5' and 3' UTR regions in a highly accurate way. UTRme implem

SUBMITTER: Radio S 

PROVIDER: S-EPMC6305552 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature