MicroRNA-590-3p inhibits trophoblast-dependent maternal spiral artery remodeling by repressing low-density lipoprotein receptor-related protein 6.

ABSTRACT:

Background

The remodeling of maternal spiral artery following embryo implantation, which relies on well-regulated trophoblast functions, is a pivotal process to ensure a successful pregnancy. Low-density lipoprotein receptor-related protein 6 (LRP6) and microRNAs (miRNAs, miRs) are suggested to be involved in angiogenesis and several vascular diseases; however, their functions in the control of trophoblast remain elusive. We therefore aimed to examine the roles of LRP6 and miR-590-3p in the regulation of trophoblast during the remodeling of maternal spiral artery.

Methods

HTR-8/SVneo cell, a trophoblast cell line, was utilized to study the effects of LRP6 and miR-590-3p on apoptosis, cell proliferation, migration, invasion, as well as tube formation. Expression of angiogenic

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6305632 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature