Functional variants of the ATG7 gene promoter in acute myocardial infarction.

ABSTRACT:

Background

Coronary artery disease including acute myocardial infarction (AMI) is mainly caused by atherosclerosis, an inflammatory and metabolic disease. Autophagy has been demonstrated to play critical roles in lipid metabolism and inflammation. Altered autophagic activity has been reported in AMI patients. However, molecular basis for dysfunctional autophagy in AMI remains unexplained.

Methods

In this study, the promoter of the ATG7 gene, encoding a core protein for autophagy, was genetically and functionally analyzed in large cohorts of AMI patients (n = 355) and ethnic-matched healthy controls (n = 363). Related molecular mechanisms were also explored.

Results

A total of 19 DNA sequence variants (DSVs) including single-nucleotide polymorphisms (SNPs) were found i

SUBMITTER: Zhang P 

PROVIDER: S-EPMC6305654 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature