Resting-State Default Mode Network Related Functional Connectivity Is Associated With Sustained Attention Deficits in Schizophrenia and Obsessive-Compulsive Disorder.

ABSTRACT: Background: Previous studies have indicated the resting-state default mode network (DMN) related connectivity serving as predictor of sustained attention performance in healthy people. Interestingly, sustained attention deficits as well as DMN-involved functional connectivity (FC) alterations are common in both patients with schizophrenia (SCZ) and with obsessive-compulsive disorder (OCD). Thus, the present study was designed to investigate whether the DMN related resting-state connectivity alterations in these two psychiatric disorders were neural correlates of their sustained attention impairments. Methods: The study included 17 SCZ patients, 35 OCD patients and 36 healthy controls (HCs). Sustained attention to response task was adopted to assess the sustained attention. Re

SUBMITTER: Fan J 

PROVIDER: S-EPMC6305719 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature