Herpes Simplex Virus Type 2 Infection-Induced Expression of CXCR3 Ligands Promotes CD4⁺ T Cell Migration and Is Regulated by the Viral Immediate-Early Protein ICP4.

ABSTRACT: HSV-2 infection-induced CXCR3 ligands are important for the recruitment of virus-specific CD8⁺ T cells, but their impact on CD4⁺ T cell trafficking remains to be further determined. Given that recruitment of CD4⁺ T cells to infection areas may be one of the mechanisms that account for HSV-2 infection-mediated enhancement of HIV-1 sexual transmission, here we investigated the functionality of HSV-2 infection-induced CXCR3 ligands CXCL9, CXCL10, and CXCL11 in vivo and in vitro, and determined the viral components responsive for such induction and the underlying mechanisms. We first found that the expression of CXCR3 ligands CXCL9, CXCL10, and CXCL11 was increased in mice following vaginal challenge with HSV-2, while CXCL9 played a predominant ro

SUBMITTER: Zhang M 

PROVIDER: S-EPMC6305738 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature