Natural Killer Cell Education Is Associated With a Distinct Glycolytic Profile.

ABSTRACT: NK cells expressing self-inhibitory receptors display increased functionality compared to NK cells lacking those receptors. The acquisition of functional competence in these particular NK-cell subsets is termed education. Little is known about the underlying mechanisms that lead to the functional differences between educated and uneducated NK cells. An increasing number of studies suggest that cellular metabolism is a determinant of immune cell functions. Thus, alterations in cellular metabolic pathways may play a role in the process of NK-cell education. Here, we compared the glycolytic profile of educated and uneducated primary human NK cells. KIR-educated NK cells showed significantly increased expression levels of the glucose transporter Glut1 in comparison to NKG2A-educated or uneduca

SUBMITTER: Pfeifer C 

PROVIDER: S-EPMC6305746 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature