Differential Expression Profile of ZFX Variants Discriminates Breast Cancer Subtypes

ABSTRACT:

Background

ZFX is a transcriptional regulator in embryonic stem cells and plays an important role in pluripotency and self-renewal. ZFX is widely expressed in pluripotent stem cells and is down-regulated during differentiation of embryonic stem cells. ZFX has five different variants that encode three different protein isoforms. While several reports have determined the overexpression of ZFX in a variety of somatic cancers, the expression of ZFX-spliced variants in cancer cells is not well-understood.

Methods

We investigated the expression of ZFX variants in a series of breast cancer tissues and cell lines using quantitative PCR.

Results

The expression of ZFX variant 1/3 was higher in tumor tissue compared to marginal tissue. In contrast, the ZFX variant 5 was down-reg

SUBMITTER: Pourkeramati F 

PROVIDER: S-EPMC6305825 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature