GABA-A and GABA-B Receptors in Filial Imprinting Linked With Opening and Closing of the Sensitive Period in Domestic Chicks (Gallus gallus domesticus).

ABSTRACT: Filial imprinting of domestic chicks has a well-defined sensitive (critical) period lasting in the laboratory from hatching to day 3. It is a typical model to investigate the molecular mechanisms underlying memory formation in early learning. We recently found that thyroid hormone 3,5,3'-triiodothyronine (T₃) is a determinant of the sensitive period. Rapid increases in cerebral T₃ levels are induced by imprinting training, rendering chicks imprintable. Furthermore, the administration of exogenous T₃ makes chicks imprintable on days 4 or 6 even after the sensitive period has ended. However, how T₃ affects neural transmission to enable imprinting remains mostly unknown. In this study, we demonstrate opposing roles for gamma-aminobutyric acid (GABA)

SUBMITTER: Aoki N 

PROVIDER: S-EPMC6305906 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature