Contactin-1 and contactin-2 in cerebrospinal fluid as potential biomarkers for axonal domain dysfunction in multiple sclerosis.

ABSTRACT:

Background

Contactin-1 and contactin-2 are important for the maintenance of axonal integrity.

Objective

To investigate the cerebrospinal fluid levels of contactin-1 and contactin-2 in multiple sclerosis patients and controls, and their potential use as prognostic markers for neurodegeneration.

Methods

Cerebrospinal fluid contactin-1 and contactin-2 were measured in relapsing-remitting multiple sclerosis (n = 41), secondary progressive multiple sclerosis (n = 26) and primary progressive multiple sclerosis patients (n = 13) and controls (n = 18), and in a second cohort with clinically isolated syndrome patients (n = 88, median clinical follow-up period of 2.3 years) and controls (n = 20). Correlations/linear regressions were ana

SUBMITTER: Chatterjee M 

PROVIDER: S-EPMC6305953 | biostudies-literature | 2018 Oct-Dec

REPOSITORIES: biostudies-literature