Metagenomic next-generation sequencing as a diagnostic tool for toxoplasmic encephalitis.

ABSTRACT:

Background

More than 100 different pathogens can cause encephalitis. Testing of all the neurological pathogens by conventional methods can be difficult. Metagenomic next-generation sequencing (NGS) could identify the infectious agents in a target-independent manner. The role of this novel method in clinical diagnostic microbiology still needs to be evaluated. In present study, we used metagenomic NGS to search for an infectious etiology in a human immunodeficiency virus (HIV)-infected patient with lethally diffuse brain lesions. Sequences mapping to Toxoplasma gondii were unexpectedly detected.

Case presentation

A 31-year-old HIV-infected patient presented to hospital in a critical ill condition with a Glasgow coma scale score of 3. Brain magnetic resonance imaging showed di

SUBMITTER: Hu Z 

PROVIDER: S-EPMC6305995 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature