Establishing Pediatric and Adult RBC Reference Intervals With NHANES Data Using Piecewise Regression.

ABSTRACT:

Objectives

To develop age- and sex-specific RBC reference intervals using the National Health and Nutrition Examination Survey (NHANES) 1999 to 2012, a large nationally representative, population-based, cross-sectional database (n = 44,328).

Methods

Comprehensive medical data were used to define a "healthy" population. Reference intervals for RBC count, hemoglobin, hematocrit, mean cell hemoglobin, mean cell hemoglobin concentration, mean cell volume, and red cell distribution width were computed using piecewise regression, an evidence-based statistical procedure that identifies breakpoints.

Results

The derived reference intervals were sex specific, unlike many current standards, and more precise for individuals of different ages, especially for children, adolescents,

SUBMITTER: Fulgoni VL 

PROVIDER: S-EPMC6306047 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature