Transcriptomic analyses identify key differentially expressed genes and clinical outcomes between triple-negative and non-triple-negative breast cancer.

ABSTRACT:

Purpose

There are significant differences in the biological behavior between triple-negative breast cancer (TNBC) and non-triple-negative breast cancer (non-TNBC). In the present study, we identify key differential genes and clinical outcomes between TNBC and non-TNBC.

Materials and methods

Transcriptomic analyses used GEO datasets (GSE76275), gene ontology, KEGG pathway analysis and cBioPortal. Quantitative RT-PCR analysis (qRT-PCR) was used to validate the differentially expressed genes. We used the KM Plotter Online Tool and 240 patients with TNBC tissue microarray to assay the prognostic value of HORMAD1.

Results

The upregulated differentially expressed genes were enriched in transcription factor activity, sequence-specific DNA binding and nucleic acid bind

SUBMITTER: Chen B 

PROVIDER: S-EPMC6306052 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature