Folic acid receptor-targeted human serum albumin nanoparticle formulation of cabazitaxel for tumor therapy.

ABSTRACT:

Background

We previously developed cabazitaxel (CTX)-loaded human serum albumin nanoparticles (NPs-CTX) via a self-assembly method, and these NPs showed efficacy in prostate cancer therapy. Many studies have shown that the levels of folic acid (FA) receptor on the surface of various tumor cells are high. Therefore, FA-modified NPs-CTX may have enhanced antitumor effects compared with unmodified NPs-CTX.

Methods

NPs-CTX were first prepared via self-assembly, and FA was conjugated on the surface of NPs-CTX through the -NH₂ groups of the NPs to produce FA-NPs-CTX. The FA-NPs-CTX were evaluated in tumor cells with high FA receptor (FR) expression in vitro and in vivo.

Results

Both NPs-CTX and FA-NPs-CTX exhibited good stability and morphology. Drug release from

SUBMITTER: Sun Y 

PROVIDER: S-EPMC6306057 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature