Injury-induced cold sensitization in Drosophila larvae involves behavioral shifts that require the TRP channel Brv1.

ABSTRACT: Nociceptive sensitization involves an increase in responsiveness of pain sensing neurons to sensory stimuli, typically through the lowering of their nociceptive threshold. Nociceptive sensitization is common following tissue damage, inflammation, and disease and serves to protect the affected area while it heals. Organisms can become sensitized to a range of noxious and innocuous stimuli, including thermal stimuli. The basic mechanisms underlying sensitization to warm or painfully hot stimuli have begun to be elucidated, however, sensitization to cold is not well understood. Here, we develop a Drosophila assay to study cold sensitization after UV-induced epidermal damage in larvae. Larvae respond to acute cold stimuli with a set of unique behaviors that include a contraction of the head an

SUBMITTER: Turner HN 

PROVIDER: S-EPMC6306221 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature