PPARγ maintains the metabolic heterogeneity and homeostasis of renal tubules.

ABSTRACT:

Background

The renal tubules, which have distant metabolic features and functions in different segments, reabsorb >99% of approximately 180 l of water and 25,000 mmol of Na ⁺ daily. Defective metabolism in renal tubules is involved in the pathobiology of kidney diseases. However, the mechanisms underlying the metabolic regulation in renal tubules remain to be defined.

Methods

We quantitatively compared the proteomes of the isolated proximal tubules (PT) and distal tubules (DT) from C57BL/6 mouse using tandem mass tag (TMT) labeling-based quantitative mass spectrometry. Bioinformatics analysis of the differentially expressed proteins revealed the significant differences between PT and DT in metabolism pathway. We also performed in vitro and in vivo assays to invest

SUBMITTER: Lyu Z 

PROVIDER: S-EPMC6306377 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature