Usefulness Differs Between the Visual Assessment and Specific Binding Ratio of ¹²³I-Ioflupane SPECT in Assessing Clinical Symptoms of Drug-Naive Parkinson's Disease Patients.

ABSTRACT: Background: In clinical practice, assessment of the striatal accumulation in ¹²³I-ioflupane single photon emission computed tomography (SPECT) is commonly performed calculating the specific binding ratio (SBR) for the whole striatum. On the other hand, visual assessment of striatal accumulation in the SPECT was recently established. However, correlations of visual assessment with motor and cognitive functions in Parkinson's disease (PD) have rarely been examined. Differences in the usefulness of these assessments at clinics are uncertain. Objective: We performed this study to compare correlations of cognitive and motor functions in drug-naive PD between the SBR and visual assessment using ¹²³I-ioflupane SPECT. Methods: Cognitive and motor assessme

SUBMITTER: Murakami H 

PROVIDER: S-EPMC6306624 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature