Evaluation of Different Decellularization Protocols on the Generation of Pancreas-Derived Hydrogels.

ABSTRACT: Different approaches have investigated the effects of different extracellular matrices (ECMs) and three-dimensional (3D) culture on islet function, showing encouraging results. Ideally, the proper scaffold should mimic the biochemical composition of the native tissue as it drives numerous signaling pathways involved in tissue homeostasis and functionality. Tissue-derived decellularized biomaterials can preserve the ECM composition of the native tissue making it an ideal scaffold for 3D tissue engineering applications. However, the decellularization process may affect the retention of specific components, and the choice of a proper detergent is fundamental in preserving the native ECM composition. In this study, we evaluated the effect of different decellularization protocols on the mechani

SUBMITTER: Gaetani R 

PROVIDER: S-EPMC6306687 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature