D3T acts as a pro-oxidant in a cell culture model of diabetes-induced peripheral neuropathy.

ABSTRACT: Diabetes mellitus is one of the most common chronic diseases in the United States and peripheral neuropathy (PN) affects at least 50% of diabetic patients. Medications available for patients ameliorate symptoms (pain), but do not protect against cellular damage and come with severe side effects, leading to discontinued use. Our research group uses differentiated SH-SY5Y cells treated with advanced glycation end products (AGE) as a model to mimic diabetic conditions and to study the mechanisms of oxidative stress mediated cell damage and antioxidant protection. N-acetylcysteine (NAC), a common antioxidant supplement, was previously shown by our group to fully protect against AGE-induced damage. We have also shown that 3H-1,2-dithiole-3-thione (D3T), a cruciferous vegetable constituent and p

SUBMITTER: Stochelski MA 

PROVIDER: S-EPMC6306693 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature