Interleukin-6 gene -572G/C polymorphism and prostate cancer risk.

ABSTRACT:

Background

The aim of the present study was to determine whether the interleukin-6 (IL-6) -572G/C polymorphism correlates with prostate cancer.

Methods

According to inclusion and exclusion criteria, the association of the IL-6 -572G/C polymorphism with prostate cancer was searched in databases and analyzed using comprehensive meta-analysis software. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the associations.

Results

We considered a total of six case-control studies including 2237 patients and 1754 controls and the meta-analysis results showed significant association between the IL-6 -572G/C polymorphism and prostate cancer risk(CC vs GG: OR = 0.49, 95% CI =0.37-0.65;CG vs GG: OR =0.71, 95% CI = 0.58-0.87; the dominant mo

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6306959 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature