Heterogeneous distribution of k13 mutations in Plasmodium falciparum in Laos.

ABSTRACT:

Background

The emergence and transnational spread of artemisinin resistance in Plasmodium falciparum in the Greater Mekong Sub-region (GMS) is a serious threat to malaria elimination in the region and could present a threat to malaria control in Africa. Recently, the Lao Government adopted the goal of malaria elimination by 2030, for which monitoring of artemisinin-resistant malaria within the country is indispensable. This study's objectives were to assess the distribution of k13 mutations in Laos.

Methods

Plasmodium falciparum isolates (n = 1151) were collected from five southern provinces in Laos between 2015 and 2016, and three isolates from the northernmost province bordering China in 2017. Polymorphisms of the k13 gene and two flanking regions were analysed to estimate

SUBMITTER: Iwagami M 

PROVIDER: S-EPMC6307170 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature