Genome rearrangements and selection in multi-chromosome bacteria Burkholderia spp.

ABSTRACT:

Background

The genus Burkholderia consists of species that occupy remarkably diverse ecological niches. Its best known members are important pathogens, B. mallei and B. pseudomallei, which cause glanders and melioidosis, respectively. Burkholderia genomes are unusual due to their multichromosomal organization, generally comprised of 2-3 chromosomes.

Results

We performed integrated genomic analysis of 127 Burkholderia strains. The pan-genome is open with the saturation to be reached between 86,000 and 88,000 genes. The reconstructed rearrangements indicate a strong avoidance of intra-replichore inversions that is likely caused by selection against the transfer of large groups of genes between the leading and the lagging strands. Translocated genes also tend to retain their po

SUBMITTER: Bochkareva OO 

PROVIDER: S-EPMC6307245 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature