Maoberry (Antidesma bunius) ameliorates oxidative stress and inflammation in cardiac tissues of rats fed a high-fat diet.

ABSTRACT:

Backgound

Chronic fat-rich diets consumption is increased risk associated with cardiovascular diseases (CVD). Prevention or reduction the progression of cardiac tissue deterioration could benefit in CVD. This study aimed to examine the effects of maoberry (Antidesma bunius), a antioxidant-rich tropical fruit, supplementation on oxidative stress and inflammation in cardiac tissues of rats fed a high-fat diet (HFD).

Methods

The male rats orally received HFD with maoberry extract doses of 0.38, 0.76 or 1.52 g/kg or simvastatin (10 mg/kg) for 12 weeks. At the end of the experimental period, the rats were fasted, euthanized and harvested for the hearts.

Results

Significantly reduced oxidative stress (malondialdehyde levels) and enhanced antioxidant capacity (ferric-reducin

SUBMITTER: Udomkasemsab A 

PROVIDER: S-EPMC6307262 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature