Association between E469K polymorphism in the ICAM1 gene and the risk of diabetic nephropathy: a meta-analysis.

ABSTRACT:

Background

Inflammation may be a key pathophysiological mechanism in diabetic nephropathy (DN). Intercellular adhesion molecule 1 (ICAM1) is an acute phase marker of inflammation. ICAM1 rs5498 has been reported to be associated with the risk of DN. However, the previous findings were conflicting due to the limited sample sizes, different methodologies and ethnicities. Therefore, this study aimed to investigate the genetic association between ICAM1 rs5498 and the risk of DN.

Methods

Two investigators independently searched the studies from the databases PubMed, Web of Science, the Cochrane Library, Chinese National Knowledge Infrastructure (CNKI) and Embase. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the associations.

Results

No si

SUBMITTER: Liu L 

PROVIDER: S-EPMC6307272 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature