Changes in H3K27ac following lipopolysaccharide stimulation of nasopharyngeal epithelial cells.

ABSTRACT:

Background

The epithelium is the first line of defense against pathogens. Notably the epithelial cells lining the respiratory track are crucial in sensing airborne microbes and mounting an effective immune response via the expression of target genes such as cytokines and chemokines. Gene expression regulation following microbial recognition is partly regulated by chromatin re-organization and has been described in immune cells but data from epithelial cells is not as detailed. Here, we report genome-wide changes of the H3K27ac mark, characteristic of activated enhancers and promoters, after stimulation of nasopharyngeal epithelial cells with the bacterial endotoxin Lipopolysaccharide (LPS).

Results

In this study, we have identified 626 regions where the H3K27ac mark showed r

SUBMITTER: Borghini L 

PROVIDER: S-EPMC6307289 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature