Important cardiac transcription factor genes are accompanied by bidirectional long non-coding RNAs.

ABSTRACT:

Background

Heart development is a relatively fragile process in which many transcription factor genes show dose-sensitive characteristics such as haploinsufficiency and lower penetrance. Despite efforts to unravel the genetic mechanism for overcoming the fragility under normal conditions, our understanding still remains in its infancy. Recent studies on the regulatory mechanisms governing gene expression in mammals have revealed that long non-coding RNAs (lncRNAs) are important modulators at the transcriptional and translational levels. Based on the hypothesis that lncRNAs also play important roles in mouse heart development, we attempted to comprehensively identify lncRNAs by comparing the embryonic and adult mouse heart and brain.

Results

We have identified spliced lncRNAs

SUBMITTER: Hori Y 

PROVIDER: S-EPMC6307297 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature