Topological Properties of Brain Structural Networks Represent Early Predictive Characteristics for the Occurrence of Bipolar Disorder in Patients With Major Depressive Disorder: A 7-Year Prospective Longitudinal Study.

ABSTRACT: Bipolar disorder (BD) and major depressive disorder (MDD) are associated with different brain functional and structural abnormalities, but BD is hard to distinguish from MDD until the first manic or hypomanic episode. The aim of this study was to examine whether the topological properties of the brain structural network could be used to differentiate BD from MDD patients before their first manic/hypomanic episode. Diffusion tensor images were collected from 80 MDD patients and 53 healthy controls (HCs); 78 patients completed the follow-up study lasting 7 years. Among them, 12 patients were converted to BD and 64 patients remained MDD. Topological properties of the brain structural networks at baseline were compared among patients who converted to BD, patients who did not develop BD, and HC

SUBMITTER: Liu H 

PROVIDER: S-EPMC6307456 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature