IL-6 Impairs Vaccine Responses in Neonatal Mice.

ABSTRACT: The inability of infants to mount proper follicular helper T (T_FH) cell response renders this age group susceptible to infectious diseases. Initial instruction of T cells by antigen presenting cells and subsequent differentiation into T_FH cells are controlled by T cell receptor signal strength, co-stimulatory molecules and cytokines such as IL-6 and IL-21. In immunized adults, IL-6 promotes T_FH development by increasing the expression of CXCR5 and the T_FH master transcription factor, B cell lymphoma 6. Underscoring the importance of IL-6 in T_FH generation, we found improved antibody responses accompanied by increased T_FH cells and decreased follicular regulatory helper T (T_FR) cells, a Foxp3 expressing inhibitory

SUBMITTER: Yang J 

PROVIDER: S-EPMC6307459 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature