Somato-Dendritic Regulation of Raphe Serotonin Neurons; A Key to Antidepressant Action.

ABSTRACT: Several lines of evidence implicate serotonin (5-hydroxytryptamine, 5-HT)in regulating personality traits and mood control. Serotonergic neurons are classically thought to be tonic regular-firing, "clock-like" neurons. Neurotransmission by serotonin is tightly regulated by the serotonin transporter (SERT) and by autoreceptors (serotonin receptors expressed by serotonin neurons) through negative feedback inhibition at the cell bodies and dendrites (5-HT_1A receptors) of the dorsal raphe nuclei or at the axon terminals (5-HT_1B receptors). In dorsal raphe neurons, the release of serotonin from vesicles in the soma, dendrites, and/or axonal varicosities is independent of classical synapses and can be induced by neuron depolarization, by the stimulation of L-type calcium ch

SUBMITTER: Quentin E 

PROVIDER: S-EPMC6307465 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature