Cardiac remodelling and haemodynamic characteristics in primary mitral valve regurgitation.

ABSTRACT:

Objective

To assess the association between cardiac morphology and function assessed with cardiac MRI (CMRI) and haemodynamics at rest and during exercise in patients with primary mitral regurgitation (MR).

Methods

In an observational study, subjects with significant primary MR (N = 46) with effective regurgitant orifice ≥ 0.30 cm² and left ventricular (LV) ejection fraction > 60% were examined with right heart catheterisation during rest and exercise and CMRI at rest. End-diastolic pressure volume relationship (EDPVR) was assessed using a single beat method using pulmonary capillary wedge pressure (PCWP) and end-diastolic volume. Patients were divided according to normal PCWP at rest (> 12 mm Hg) and with exercise (> 28 mm Hg). Results: Resting regurgitant volume

SUBMITTER: Bakkestrom R 

PROVIDER: S-EPMC6307562 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature