New score for assessing bleeding risk in patients with atrial fibrillation treated with NOACs.

ABSTRACT:

Background

Information is needed on bleeding risk factors specific for patients with atrial fibrillation (AF) treated with non-vitamin K oral anticoagulants (NOACs). We aimed to identify risk factors in a large real-world cohort and to derive a bleeding risk score for patients with AF treated with NOACs.

Methods

From nationwide registries (the Norwegian Patient Registry and the Norwegian Prescription Database), we identified patients with AF with a first prescription of a NOAC between January 2013 and June 2015. Cox proportional-hazards analysis was used to identify the strongest risk factors for major or clinically relevant non-major (CRNM) bleeding. Based on these, a risk prediction score was derived. Discrimination was assessed with Harrel's C-index. C-indexes for the mod

SUBMITTER: Rutherford OW 

PROVIDER: S-EPMC6307577 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature