Overexpression of PDK4 is associated with cell proliferation, drug resistance and poor prognosis in ovarian cancer.

ABSTRACT:

Purpose

Ovarian cancer is a major type of gynecological malignancy which characterized by the chemoresistance, heterogeneity and highly metastasis. However, the mechanism underlying the progression of ovarian cancer remains elusive. Pyruvate dehydrogenase kinase family plays critical roles in tumorigenesis, and PDK4 has been demonstrated to be an oncogene in many types of cancers. The aim of this study was to identify the role of PDK4 in ovarian cancer.

Methods

We explored the PDK4 expression according to the public database containing patients with different effect of chemotherapy. Cell proliferation and invasion assays were used to determine the function of PDK4. Mice xenograft experiment was conducted to test the pro-tumorigenesis function of PDK4 in vivo. Cell apoptosis

SUBMITTER: Wang J 

PROVIDER: S-EPMC6307676 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature